The pathophysiology of otosclerosis: Review of current research.

The pathophysiology of otosclerosis: Review of current research.
Hear Res. 2015 Aug 11;
Authors: Rudic M, Keogh I, Wagner R, Wilkinson E, Kiros N, Ferrary E, Sterkers O, Bozorg Grayeli A, Zarkovic K, Zarkovic N
Abstract
Otosclerosis is a complex disease of the human otic capsule with highest incidence in adult Caucasians. So far, many possible etiological factors like genetics, HLA, autoimmunity, viruses, inflammation, and hormones have been investigated but still the development of the disease remains unclear. Currently, the surgical replacement of stapes (stapedotomy) remains the best possible treatment option. In this review, we analyze different etiological factors studied so far in otosclerosis pathophysiology and discuss most recent findings and possible new research pathways.
PMID: 26276418 [PubMed - as supplied by publisher]

Source: Hearing Research - August 11, 2015 Category: Audiology Authors: Rudic M, Keogh I, Wagner R, Wilkinson E, Kiros N, Ferrary E, Sterkers O, Bozorg Grayeli A, Zarkovic K, Zarkovic N Tags: Hear Res Source Type: research