MicroRNA regulation of allergic inflammation and asthma.

MicroRNA regulation of allergic inflammation and asthma.
Curr Opin Immunol. 2015 Aug 4;36:101-108
Authors: Pua HH, Ansel KM
Abstract
Allergic diseases are prevalent and clinically heterogeneous, and are the pathologic consequence of inappropriate or exaggerated type 2 immune responses. In this review, we explore the role of microRNAs (miRNAs) in regulating allergic inflammation. We discuss how miRNAs, acting through target genes to modulate gene expression networks, impact multiple facets of immune cell function critical for type 2 immune responses including cell survival, proliferation, differentiation, and effector functions. Human and mouse studies indicate that miRNAs are significant regulators of allergic immune responses. Finally, investigations of extracellular miRNAs offer promise for noninvasive biomarkers and therapeutic strategies for allergy and asthma.
PMID: 26253882 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - August 4, 2015 Category: Allergy & Immunology Authors: Pua HH, Ansel KM Tags: Curr Opin Immunol Source Type: research