Gi highlights from the literature

Basic scienceUnderstanding the pathogenesis of pouchitis Morgan XC, Kabakchiev B, Waldron L, et al. Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease. Genome Biol 2015:16:67. doi:10.1186/s13059-015-0637-x Approximately 10%–35% of patients with UC will require colectomy with pouch reconstruction, and half of these patients will develop pouchitis. In addition, one-fifth will ultimately suffer pouch failure. Therefore, defining the basis of pouchitis is clearly of utmost importance. Similar to IBD, both host genetics and the microbiota are implicated in the pathogenesis of pouchitis. However, how these factors interact in this condition is not well understood. Interestingly, pouch construction is also performed for patients with familial adenomatous polyposis, although pouchitis is rare in this group. To investigate the basis of potential host–microbe interactions, this study by Morgan and colleagues collected paired host transcriptome and microbial metagenome...
Source: Gut - Category: Gastroenterology Authors: Tags: JournalScan Source Type: research