How Center Volumes Affect Early Outcomes in Acute Myeloid Leukemia

Publication date: Available online 5 August 2015 Source:Clinical Lymphoma Myeloma and Leukemia Author(s): Andrew W. Hahn, Omer Jamy, Sara Nunnery, George Yaghmour, Smith Giri, Ranjan Pathak, Mike G. Martin Early mortality (EM) is all too frequent during induction chemotherapy for acute myeloid leukemia (AML). Older patients shoulder an undue amount of this burden due to the inherent biology of their disease and increased co-morbidities. EM rates in academic centers have seen a sharp decline over the past twenty years; however, data from population-based registries show that EM rates for the general population have significantly lagged behind. In this review, we will analyze the data available on EM in academic centers and the general population, explore recent improvements in supportive care and the use of predictive models, and finally investigate the relationship between case volume and complications during chemotherapy.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research