Synergistic suppression of human breast cancer cells by combination of plumbagin and zoledronic acid In vitro.

CONCLUSION: Combination of ZA and PL synergistically suppresses human breast cancer MDA-MB-231SArfp cells in vitro. PL can inhibit ZA-induced activation of the Notch-1 signaling pathway and subsequently reduce the expression of Bcl-2, thus potentiating cancer cell apoptosis. PMID: 26235741 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26235741?dopt=Abstract

Source: Acta Pharmacologica Sinica - August 3, 2015 Category: Drugs & Pharmacology Authors: Qiao H, Wang TY, Yan W, Qin A, Fan QM, Han XG, Wang YG, Tang TT Tags: Acta Pharmacol Sin Source Type: research