TIMP-1 resistant matrix metalloproteinase-9 is the predominant serum active isoform associated with MRI activity in patients with multiple sclerosis

Conclusion:
Our findings suggested that the TIMP-1 resistant MMP-9 seem to be the predominantly active isoform contributing to MS disease activity.

Source: Multiple Sclerosis - July 23, 2015 Category: Neurology Authors: Trentini, A., Manfrinato, M. C., Castellazzi, M., Tamborino, C., Roversi, G., Volta, C. A., Baldi, E., Tola, M. R., Granieri, E., Dallocchio, F., Bellini, T., Fainardi, E., the Emilia-Romagna network for Multiple Sclerosis (ERMES) study group, Granieri, C Tags: Original Research Papers Source Type: research