Glycoprotein IIb/IIIa inhibitors: The resurgence of tirofiban.

Glycoprotein IIb/IIIa inhibitors: The resurgence of tirofiban.
Vascul Pharmacol. 2015 Jul 15;
Authors: King S, Short M, Harmon C
Abstract
Glycoprotein (GP) IIb/IIIa inhibitors block platelet aggregation, reducing thrombotic events in acute coronary syndrome. They are most often utilized in patients who likely have an intracoronary thrombus. Tirofiban, eptifibatide, and abciximab are the three GP IIb/IIIa inhibitors approved for use in the United States. Each agent has unique pharmacological properties. They all have a rapid onset and are most often utilized in conjunction with heparin. Tirofiban, in particular, fell out of favor due to inferior dosing with its original Food and Drug Administration (FDA) approved indication, but has re-emerged in the market with a high-dose bolus regimen that is considered equally as effective as the FDA approved dosing regimens of other GP IIb/IIIa inhibitors. This review looks at pharmacological properties of all three agents, significant clinical trials associated with their use, and their place in current guidelines.
PMID: 26187354 [PubMed - as supplied by publisher]

Source: Vascular Pharmacology - July 15, 2015 Category: Drugs & Pharmacology Authors: King S, Short M, Harmon C Tags: Vascul Pharmacol Source Type: research