Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis

Conclusion. RA activity correlated with decreased synovial fluid pH. This may be due to increased MCT4 expression in RASFs. Silencing MCT4 induced apoptosis in RASFs and reduced the severity of CIA, suggesting that MCT4 is a potential therapeutic target for inflammatory arthritis. This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - July 20, 2015 Category: Rheumatology Authors: Wataru Fujii, Yutaka Kawahito, Hidetake Nagahara, Yuji Kukida, Takahiro Seno, Aihiro Yamamoto, Masataka Kohno, Ryo Oda, Daigo Taniguchi, Hiroyoshi Fujiwara, Akika Ejima, Tsunao Kishida, Osam Mazda, Eishi Ashihara Tags: Full Length Source Type: research