Combination of diminazene aceturate and resveratrol reduces the toxic effects of chemotherapy in treating Trypanosoma evansi infection

Abstract The aim of this study was to evaluate the effects of resveratrol (RSV) in its free or complexed (cyclodextrin) forms in association with diminazene aceturate (DA), as an attempt to reduce the toxic effects of this standard chemotherapy on renal and hepatic samples of mice experimentally infected with T. evansi. In this sense, this experiment was designed in order to test the ability of RSV, in its free or complexed forms, on reducing the damage on lipid membrane and protein oxidation, effects usually observed by using DA. Both forms of RSV were used at 100 mg kg−1, during seven consecutive days. As a result, it was observed that, on renal and hepatic samples, RSV in its free form, when combined with DA, was able to inhibit the increase of thiobarbituric acid reactive species levels. DA caused a decrease in the hepatic levels of advanced oxidation protein products, suggesting changes in protein synthesis; however, when it was combined with RSV, this deleterious effect was not observed. It demonstrates that RSV was able to provide some grade of protection against protein oxidation. Therefore, RSV may represent an alternative in reducing the toxic effect caused by chemotherapy in treating of T. evansi infection.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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In conclusion, the combination of chemotherapy and glucose restriction was observed to decrease Ca-125 secretion and telomerase expression leading to shortening in telomere length. Thus, decreasing glucose availability for OC cells during treatment may lead to a better clinical outcome and potentially improve the prognosis of patients with OC. PMID: 31966066 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, high methylation levels of the PD-L1 promoter region may be a faciliatory mechanism enabling gastric cancer tumorigenesis, and may also represent an independent prognostic factor for chemotherapeutic efficacy in patients with advanced gastric cancer. PMID: 31966052 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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Source: Peptides - Category: Biochemistry Source Type: research
The objective was to compare post-operative complication rates among patients treated with partial mastectomy (PM), unilateral mastectomy (UM), and bilateral mastectomy (BM) after NAC.Study design398 patients with breast cancer who had NAC from 2008 to 2016 were identified from a prospectively maintained database. The primary outcome measure was 30-day post-operative morbidity.Results125 patients (31.4%) underwent PM, 107 patients (26.9%) UM, and 166 (41.7%) BM. There was no significant difference among the 3 groups with respect to histology (ductal: 96.0% PM, 88.8% UM, 92.6% BM, p = 0.161). Groups were similar with re...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionDiagnosis and management of pituitary metastases are complex and depend on many factors. Endoscopic surgical resection and debulking alleviates symptoms and provides the definitive diagnosis which has great importance in cases with clinical presentation that does not strongly point to pituitary metastasis to avoid unnecessary radiotherapy and chemotherapy when possible.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We report a case of a 67-year-old female with mediastinal metastasis from ovarian cancer 29 years after initial gynecologic surgery and chemotherapy.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Conclusion: Epithelioid GBM is one of the rarest morphologic subtypes of GBM and has a strongly infiltrative and aggressive nature. Therefore, careful identification of preoperative imaging studies and detailed evaluation of genetic studies are necessary to select the appropriate treatment for epithelioid GBM. PMID: 31966927 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusions: This is the third case of primary ES of the petroclival bone to be reported in the literature. In this patient, management consisted of surgical incisional biopsy followed by adjuvant radiation and chemotherapy. Knowledge and awareness of this type of tumor is important for the skull base surgeon. PMID: 31966925 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
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Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Publication date: Available online 23 January 2020Source: Best Practice &Research Clinical HaematologyAuthor(s): Sydney Lu, Assistant Attending, Myeloma ServiceAbstractOver the course of the past decade-plus, the therapy of newly diagnosed multiple myeloma has seen incredible advances in the domains of diagnostic evaluation, active medical therapy, and response evaluation. This manuscript reviews the evaluation and management of newly diagnosed active multiple myeloma, with a focus on major clinical trials and IMWG recommendations. The paper describes a current approach for the initial evaluation and workup of a patien...
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research
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