Differential Reduction in Monocyte Activation and Vascular Inflammation With Integrase Inhibitor-Based Initial Antiretroviral Therapy Among HIV-Infected Individuals

Conclusions. EVG/c/FTC/TDF led to greater decreases in sCD14, hsCRP, and Lp-PLA2 levels, compared with EFV/FTC/TDF. Randomization group independently predicted the change in sCD14 level, and changes in monocyte activation independently predicted the change in Lp-PLA2 level. There appears to be a more favorable effect of the integrase inhibitor EVG over efavirenz on immune activation, which may affect vascular inflammation.

Source: The Journal of Infectious Diseases - July 10, 2015 Category: Infectious Diseases Authors: Hileman, C. O., Kinley, B., Scharen-Guivel, V., Melbourne, K., Szwarcberg, J., Robinson, J., Lederman, M. M., Mccomsey, G. A. Tags: HIV/AIDS Source Type: research