MicroRNAs in the Pathogenesis of Preeclampsia-A Case-Control In Silico Analysis

The objective of this secondary analysis was to elucidate the pathogenesis of PE by probing protein-protein interactions from in silico analysis of transcriptomes between PE and normal placenta from Gene Expression Omnibus (GSE149812). The pathogenesis of PE is apparently determined by associations of miRNA molecules and their target genes and the degree of changes in their expressions with irregularities in the functions of hemostasis, vascular systems, and inflammatory processes at the fetal-maternal interface. These irregularities ultimately lead to impaired placental growth and hypoxic injuries, generally manifesting as placental insufficiency. These differentially expressed miRNAs or genes in placental tissue and/or in blood can serve as novel diagnostic and therapeutic biomarkers.PMID:38666946 | PMC:PMC11048894 | DOI:10.3390/cimb46040216
Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Source Type: research