Effects of crotamine in human prostate cancer cell line

Toxicon. 2024 May 2:107746. doi: 10.1016/j.toxicon.2024.107746. Online ahead of print.ABSTRACTOur study presents the anticancer potential of crotamine from Crotalus durissus terrificus in human prostate cancer cell line DU-145. Crotamine isolation was conducted through RP-FPLC, its molecular mass analyzed by MALDI-TOF was 4881.4 kDa, and N-terminal sequencing confirmed crotamine identity. Crotamine demonstrated no toxicity and did not inhibit migration in HUVEC cells. Although no cell death occurred in DU-145 cells, crotamine inhibited their migration. Thus, crotamine presented potential to be a prototype of anticancer drug.PMID:38704124 | DOI:10.1016/j.toxicon.2024.107746

Source: Toxicon - May 4, 2024 Category: Toxicology Authors: Jo ão Victor Alberghini-Dos-Santos Caroline Andolfato Sanchez Karla de Castro Figueiredo Bordon Manuela Berto Pucca Lus ânia Maria Greggi Antunes Eliane Candiani Arantes Isadora Sousa de Oliveira Source Type: research