Decreasing circ_0014614 promotes the differentiation of bone marrow flineage cells into megakaryocytes in essential thrombocythemia via activiation of miR-138-5p/caspase3 axis

CONCLUSION: Circ_0014614 was down-regulated in ET bone marrow and bone marrow lineage cells, and upregulating circ_0014614 can inhibit bone marrow lineage cells' proliferation and differentiation into megakaryocytes. Mechanistically, circ_0014614 functioned as ceRNA via sponging miR-138-5p and alleviated the inhibitory effect of miR-138-5p on its target caspase3, which potentially deters tumor activity in ET.PMID:38703475 | DOI:10.1016/j.bcmd.2024.102855

Source: Blood Cells, Molecules and Diseases - May 4, 2024 Category: Hematology Authors: Guopan Yu Xiaofan Chen Weixiang Lu Yanlin Li Yanxiao Chen Changxin Yin Zhongxin Zheng Xiaoshan Huang Dan Xu Source Type: research