Tanshinone IIA alleviates pulmonary fibrosis by modulating glutamine metabolic reprogramming based on [U- < sup > 13 < /sup > C < sub > 5 < /sub > ]-glutamine metabolic flux analysis
CONCLUSION: Tan IIA reverses glutamine metabolic reprogramming, reduces mitochondrial energy expenditure, and inhibits collagen matrix synthesis by modulating potential targets in glutamine metabolism. This novel perspective sheds light on the essential role of glutamine metabolic reprogramming in PF.PMID:38697470 | DOI:10.1016/j.jare.2024.04.029
Source: Cell Research - Category: Cytology Authors: Baixi Shan Congying Guo Haoyan Zhou Jun Chen Source Type: research