Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation

Conclusions
GSDMB promotes ISGs expression and airway inflammation upon respiratory virus infection, thereby conferring asthma risk in risk allele carriers.

Source: European Respiratory Journal - May 2, 2024 Category: Respiratory Medicine Authors: Liu, T., Liu, S., Rui, X., Cao, Y., Hecker, J., Guo, F., Zhang, Y., Gong, L., Zhou, Y., Yu, Y., Krishnamoorthyni, N., Bates, S., Chun, S., Boyer, N., Xu, S., Park, J.-A., Perrella, M. A., Levy, B. D., Weiss, S. T., Mou, H., Raby, B. A., Zhou, X. Tags: Mechanisms of lung disease Original Research Articles Source Type: research