Sleep-wake behavior, perceived fatigability, and cognitive reserve in older adults

DISCUSSION: SRI can amplify impaired cognitive abilities through exacerbation of fatigability in patients with aMCI with below-mean CR. Therefore, improving sleep-wake regulation and leisure activities may protect against fatigability and cognitive decline.HIGHLIGHTS: Clinical fatigue and fatigability cannot be alleviated by rest. Clinical fatigability disrupts daily activities during preclinical Alzheimer's. High cognitive reserve mitigates sleep-wake disturbance effects. High cognitive reserve attenuates clinical fatigability effects on daily functioning. Untreated obstructive sleep apnea potentiates Alzheimer's pathology in the brain.PMID:38690777 | DOI:10.1002/alz.13802

Source: The Journal of Alzheimers Association - May 1, 2024 Category: Psychiatry Authors: Nancy Kerner Terry E Goldberg Hannah R Cohen Julia G Phillips Daniel E Cohen Howard Andrews Gregory Pelton Davangere P Devanand Source Type: research