Interaction between sex and GBA mutations influences clinical phenotype in Parkinson disease

Background: Biological sex differences are known to be an important factor with clinical implications in Parkinson's disease (PD). However, the role of sex in the context of PD genetic background remains largely unexplored. GBA mutations are a well-known genetic risk factor for PD. We investigated the potential interaction of sex and GBA mutations on the heterogenicity of PD clinical phenotype.

Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: L. Gallo, M. Avenali, S. Caminiti, P. Mitrotti, M. Pocora, G. Cuconato, I. Palmieri, C. Pasquini, C. Galandra, R. Calabrese, R. Zangaglia, C. Tassorelli, A.V.H. Schapira, E.M. Valente, F. Blandini Source Type: research