Viruses, Vol. 16, Pages 720: Low-Level Viremia among Adults Living with HIV on Dolutegravir-Based First-Line Antiretroviral Therapy Is a Predictor of Virological Failure in Botswana
Viruses, Vol. 16, Pages 720: Low-Level Viremia among Adults Living with HIV on Dolutegravir-Based First-Line Antiretroviral Therapy Is a Predictor of Virological Failure in Botswana
Viruses doi: 10.3390/v16050720
Authors:
Ontlametse T. Bareng
Sikhulile Moyo
Mbatshi Mudanga
Kagiso Sebina
Catherine K. Koofhethile
Wonderful T. Choga
Natasha O. Moraka
Dorcas Maruapula
Irene Gobe
Modisa S. Motswaledi
Rosemary Musonda
Bornapate Nkomo
Dinah Ramaabya
Tony Chebani
Penny Makuruetsa
Joseph Makhema
Roger Shapiro
Shahin Lockman
Simani Gaseitsiwe
We evaluated subsequent virologic outcomes in individuals experiencing low-level virem ia (LLV) on dolutegravir (DTG)-based first-line antiretroviral therapy (ART) in Botswana. We used a national dataset from 50,742 adults who initiated on DTG-based first-line ART from June 2016–December 2022. Individuals with at least two viral load (VL) measurements post three months on DTG-based first-line ART were evaluated for first and subsequent episodes of LLV (VL:51–999 copies/mL). LLV was sub-categorized as low-LLV (51–200 copies/mL), medium-LLV (201–400 copies/mL) and high-LLV (401–999 copies/mL). The study outcome was virologic failure (VF) (VL ≥ 1000 copies/mL): virologic non-suppression defined as single-VF and confirmed-VF defined as two-consecutive VF measurements after an initial VL < 1000 copies/mL. Cox regressio...
Source: Viruses - Category: Virology Authors: Ontlametse T. Bareng Sikhulile Moyo Mbatshi Mudanga Kagiso Sebina Catherine K. Koofhethile Wonderful T. Choga Natasha O. Moraka Dorcas Maruapula Irene Gobe Modisa S. Motswaledi Rosemary Musonda Bornapate Nkomo Dinah Ramaabya Tony Chebani Penny Makuruetsa Tags: Article Source Type: research