Viruses, Vol. 16, Pages 720: Low-Level Viremia among Adults Living with HIV on Dolutegravir-Based First-Line Antiretroviral Therapy Is a Predictor of Virological Failure in Botswana

Viruses, Vol. 16, Pages 720: Low-Level Viremia among Adults Living with HIV on Dolutegravir-Based First-Line Antiretroviral Therapy Is a Predictor of Virological Failure in Botswana Viruses doi: 10.3390/v16050720 Authors: Ontlametse T. Bareng Sikhulile Moyo Mbatshi Mudanga Kagiso Sebina Catherine K. Koofhethile Wonderful T. Choga Natasha O. Moraka Dorcas Maruapula Irene Gobe Modisa S. Motswaledi Rosemary Musonda Bornapate Nkomo Dinah Ramaabya Tony Chebani Penny Makuruetsa Joseph Makhema Roger Shapiro Shahin Lockman Simani Gaseitsiwe We evaluated subsequent virologic outcomes in individuals experiencing low-level virem ia (LLV) on dolutegravir (DTG)-based first-line antiretroviral therapy (ART) in Botswana. We used a national dataset from 50,742 adults who initiated on DTG-based first-line ART from June 2016–December 2022. Individuals with at least two viral load (VL) measurements post three months on DTG-based first-line ART were evaluated for first and subsequent episodes of LLV (VL:51–999 copies/mL). LLV was sub-categorized as low-LLV (51–200 copies/mL), medium-LLV (201–400 copies/mL) and high-LLV (401–999 copies/mL). The study outcome was virologic failure (VF) (VL ≥ 1000 copies/mL): virologic non-suppression defined as single-VF and confirmed-VF defined as two-consecutive VF measurements after an initial VL < 1000 copies/mL. Cox regressio...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research