Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects

CONCLUSIONS: Lifetime MDD was characterized by reduced rACC GABA+ as well as dysregulated cortisol-related interactions between top-down control (frontoparietal) and threat (task-related) networks. These findings warrant further investigation of the role of GABA in the vulnerability to and treatment of MDD.PMID:38685857 | DOI:10.1176/appi.ajp.20230382

Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Maria Ironside Jessica M Duda Amelia D Moser Laura M Holsen Chun S Zuo Fei Du Sarah Perlo Christine E Richards Xi Chen Lisa D Nickerson Kaylee E Null Shiba M Esfand Madeline M Alexander David J Crowley Meghan Lauze Madhusmita Misra Jill M Goldstein Diego Source Type: research