Evaluation of Various Approaches to Estimate Transplacental Clearance of Vancomycin for Predicting Fetal Concentrations using a Maternal –Fetal Physiologically Based Pharmacokinetic Model

ConclusionOur study showcased that combination ofex vivo human placenta perfusion experiments and m-f PBPK model has the capability to predict fetal exposure for the large molecular weight drug vancomycin, whereas otherin silico approaches failed to achieve the same level of accuracy.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research