Hypofractionated Radiation Therapy Suppresses Radioresistance in U87 Human Glioma Cells by Inhibiting Yap1 and Hsp90 Proteins

CONCLUSION: For this purpose, expression levels of radioresistance markers Yap-1 and Hsp90 were evaluated after treatment with HF-GKRT, and this was compared with single fraction Gamma Knife radiation therapy (SF-GKRT) in U87MG primary human glioblastoma cell line model. This would help design a novel radiation therapy regimen for glioblastoma patients by reducing the risk of radioresistance.PMID:38685786 | DOI:10.2174/0118744710300495240409074900

Source: Current Radiopharmaceuticals - April 30, 2024 Category: Radiology Authors: Imran Khan Sadaf Mahfooz Busra Karacam Elif Burce Elbasan Kerime Akdur Ganime Coban Mustafa Aziz Hatiboglu Source Type: research