Technological advancements in functional interpretation of genome ‐wide association studies (GWAS) findings: bridging the gap to clinical translation

Genome-wide association studies (GWAS) significantly advanced our understanding of the genetic underpinnings of diseases. However, challenges persist, particularly in interpreting non-coding variants in linkage disequilibrium that affect genes in disease-relevant cells. Addressing key obstacles —identifying causal variants, uncovering target genes, and understanding their network impact—is crucial. This graphical review navigates advanced techniques to fully leverage GWAS for future therapeutic breakthroughs.

Source: FEBS Letters - April 30, 2024 Category: Biochemistry Authors: Redouane Aherrahrou, Minna U Kaikkonen Tags: Graphical Review Source Type: research