Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis

CONCLUSIONS: These findings suggested that melatonin inhibited IAV infection, improved lung function and lung damages of AECOPD via suppressing IL-1β/STAT1-driven macrophage M1 polarization and apoptosis in a MTs-dependent manner. Melatonin may be considered as a potential therapeutic agent for influenza virus infection-induced AECOPD.PMID:38678295 | PMC:PMC11056066 | DOI:10.1186/s12931-024-02815-0

Source: Respiratory Care - April 27, 2024 Category: Respiratory Medicine Authors: Meng-Meng Xu Jia-Ying Kang Qiu-Yan Wang Xing Zuo Yuan-Yuan Tan Yuan-Yuan Wei Da-Wei Zhang Ling Zhang Hui-Mei Wu Guang-He Fei Source Type: research