442. Using a Fixed-Capacity Model of Working Memory to Understand Brain Activity During Motivated Behavior in Schizophrenia

Deficits in motivation and cognitive control are significantly disabling and treatment resistant aspects of schizophrenia (SZ). While these features are often studied in isolation, they are integrated in striato-frontal circuitry and modulated by dopamine. Using fMRI, we investigated mechanisms of reward and cognitive control thought to contribute to approach-motivation abnormalities in individuals with SZ. We hypothesized that SZs would show a decreased ability to modulate performance to increasing rewards, which would be reflected by reduced striato-frontal activity.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Tyler Lesh, Joshua Rhilinger, Tiffany Chen, Marina Albuquerque, Sarvenaz Pakzad, Lia Gugava, Timothy Hanks, Randall O'Reilly, Cameron Carter Source Type: research