454. Elevated Intrinsic Cortical Curvature in Treatment-Resistant Schizophrenia: Structural Deformation of Functional Activity Areas

Growing research shows abnormal brain structure and connectivity in patients with treatment-resistant schizophrenia (TRS) compared to first-line-responders (TxR) and healthy-controls (HC). While differences are documented as early as first-episode-psychosis (FEP), structural and connectivity measures including thickness, volume, functional connectivity, and diffusion, show susceptibility to antipsychotic treatment and interpatient heterogeneity that may limit their clinical and research use for TRS.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Edgardo Torres Carmona, Fumihiko Ueno, Yusuke Iwata, Shinichiro Nakajima, Jianmeng Song, Wanna Mar, Ali Abdolizadeh, Sri Mahavir Agarwal, Vincenzo De Luca, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrero Source Type: research