Top Stories on arrhythmias in TANGO2 deficiency disorder

TANGO2 deficiency disorder (TDD) is a multisystem neurodegenerative disease first discovered by Lalani et  al in 2016.1 This autosomal recessive disorder affects more than 8000 patients worldwide. About 1:500 individuals harbor a pathogenic TANGO2 variant that, notably, resides within the 22q11.21 locus. Thus, all patients with 22q11.21 deletion (DiGeorge) syndrome who are missing 1 copy of TANGO2 (tra nsportation and golgi organization homolog 2) are at risk of having both disorders should they harbor a second pathogenic allele.
Source: Heart Rhythm - Category: Cardiology Authors: Tags: Top Stories: Pediatric Electrophysiology Source Type: research