SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis

CONCLUSIONS: Our findings revealed that SF3B3 promoted CRC progression and metastasis by regulating mTOR alternative splicing and SREBF1-FASN-mediated lipogenesis, providing strong evidence to support SF3B3 as a druggable target for CRC therapy.PMID:38671459 | DOI:10.1186/s13046-024-03053-4

Source: Clinical Colorectal Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Tong Xu Xichuan Li Wennan Zhao Xue Wang Leixin Jin Zhiqiang Feng Huixiang Li Mingzhe Zhang Yiqing Tian Ge Hu Yuan Yue Xintong Dai Changliang Shan Weihua Zhang Chunze Zhang Youcai Zhang Source Type: research