Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Conclusion. Taken together, the results of present study indicate that the expression of genes responsible for serine synthesis is sensitive to glucose and glutamine deprivations in gene-specific manner and that suppression of ERN1 signaling significantly modifies the impact of both glucose and glutamine deprivations on PHGDH, PSAT1, PSPH, ATF4, and SHMT1 gene expressions and reflects the ERN1-mediated genome reprograming introduced by nutrient deprivation condition.PMID:38656254 | DOI:10.2478/enr-2024-0010

Source: Endocrine Regulations - April 24, 2024 Category: Endocrinology Authors: Oleksandr H Minchenko Myroslava Y Sliusar Olena O Khita Dmytro O Minchenko Yuliia M Viletska Oleh V Halkin Liudmyla O Levadna Anastasiia A Cherednychenko Yevgen P Khikhlo Source Type: research