Cervical microbiota dysbiosis associated with high-risk Human Papillomavirus infection

In this study we identified significantly lower abundance ofLactobacillus mucosae in women with HR-HPV infection compared to the control group. Furthermore, changes in bacterial diversity were noted inLactobacillus non-dominant (LND) samples compared toLactobacillus-dominant (LD) in both HR-HPV-infected and control groups. LND samples in HR-HPV-infected women exhibited a cervical dysbiotic state, characterized byLactobacillus deficiency. In turn, the LD HR-HPV group showed an overrepresentation ofLactobacillus helveticus. In summary, our study highlighted the distinctive roles ofL.mucosae andL.helveticus in HR-HPV infections, signaling a need for further research to demonstrate potential clinical implications of cervical microbiota dysbiosis.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research