Embryonic microglia maintain the brain's cortical fault lines

Trends Immunol. 2024 Apr 24:S1471-4906(24)00074-7. doi: 10.1016/j.it.2024.04.005. Online ahead of print.ABSTRACTLawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.PMID:38664101 | DOI:10.1016/j.it.2024.04.005
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Source Type: research