Cancers, Vol. 16, Pages 1688: Association of miR-146a-5p and miR-21-5p with Prognostic Features in Melanomas

Cancers, Vol. 16, Pages 1688: Association of miR-146a-5p and miR-21-5p with Prognostic Features in Melanomas Cancers doi: 10.3390/cancers16091688 Authors: Maria Naddeo Elisabetta Broseghini Federico Venturi Sabina Vaccari Barbara Corti Martina Lambertini Costantino Ricci Beatrice Fontana Giorgio Durante Milena Pariali Biagio Scotti Giulia Milani Elena Campione Manuela Ferracin Emy Dika Background: Cutaneous melanoma (CM) is one of the most lethal tumors among skin cancers and its incidence is rising worldwide. Recent data support the role of microRNAs (miRNAs) in melanoma carcinogenesis and their potential use as disease biomarkers. Methods: We quantified the expression of miR-146a-5p and miR-21-5p in 170 formalin-fixed paraffin embedded (FFPE) samples of CM, namely 116 superficial spreading melanoma (SSM), 26 nodular melanoma (NM), and 28 lentigo maligna melanoma (LMM). We correlated miRNA expression with specific histopathologic features including Breslow thickness (BT), histological subtype, ulceration and regression status, and mitotic index. Results: miR-146a-5p and miR-21-5p were significantly higher in NM compared to SSM and LMM. The positive correlation between miR-146a-5p and miR-21-5p expression and BT was confirmed for both miRNAs in SSM. Considering the ulceration status, we assessed that individual miR-21-5p expression was significantly higher in ulcerated CMs. The increased combined expression of the two miRNAs was strongly as...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research