3C methods in cancer research: recent advances and future prospects

Experimental & Molecular Medicine, Published online: 25 April 2024; doi:10.1038/s12276-024-01236-9The research explores the 3D structure of chromatin—a combination of DNA and proteins in our cells, and its role in cancer. Using Hi-C technology, a method that maps the closeness of different DNA regions within the cell nucleus, researchers have gained insights into these 3D structures, especially in cancer cells. The study involves data analysis using Hi-C to investigate chromatin’s spatial arrangement and its implications for cancer. By studying interactions between various DNA regions, researchers identify crucial chromatin structures and understand how changes in these structures contribute to cancer. The findings reveal that disruptions in chromatin structure, such as altered interactions between enhancer, promoter, and the formation of additional DNA, play a significant role in cancer development. These insights could lead to new diagnostic and treatment strategies, focusing on targeting the 3D chromatin structure in cancer cells.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research