The HGF/Met Receptor Mediates Cytotoxic Effect of Bacterial Cyclodipeptides in Human Cervical Cancer Cells

CONCLUSION: Data provide new insights into the molecular mechanisms involved in CDPs cytotoxicity and antiproliferative effects, suggesting that the signal transduction mechanism may be related to the inhibition of the phosphorylation of the EGF/MET receptor at the level of substrate binding site by an inhibition mechanism similar to that of Gefitinib and foretinib anti-neoplastic drugs.PMID:38629372 | DOI:10.2174/0115680096285034240323035013

Source: Current Cancer Drug Targets - April 17, 2024 Category: Cancer & Oncology Authors: Laura Hern ández-Padilla Mayra X Dur án-Maldonado Lorena Mart ínez-Alcantar Jos é S Rodríguez-Zavala Jesus Campos-Garcia Source Type: research