Development and Validation of an 18-Gene Urine Test for High-Grade Prostate Cancer

CONCLUSIONS AND RELEVANCE: In this study, a new 18-gene PCa test had higher diagnostic accuracy for high-grade PCa relative to existing biomarker tests. Clinically, use of this test would have meaningfully reduced unnecessary biopsies performed while maintaining highly sensitive detection of high-grade cancers. These data support use of this new PCa biomarker test in patients with elevated PSA levels to reduce the potential harms of PCa screening while preserving its long-term benefits.PMID:38635241 | DOI:10.1001/jamaoncol.2024.0455

Source: Ann Oncol - April 18, 2024 Category: Cancer & Oncology Authors: Jeffrey J Tosoian Yuping Zhang Lanbo Xiao Cassie Xie Nathan L Samora Yashar S Niknafs Zoey Chopra Javed Siddiqui Heng Zheng Grace Herron Neil Vaishampayan Hunter S Robinson Kumaran Arivoli Bruce J Trock Ashley E Ross Todd M Morgan Ganesh S Palapattu Simpa Source Type: research