Urease and human glioblastoma (U87) cells growth inhibitory iridoid glycoside acetates from < em > Nyctanthes arbor-tristis < /em > Linn

Nat Prod Res. 2024 Apr 22:1-9. doi: 10.1080/14786419.2024.2340059. Online ahead of print.ABSTRACTThe present study was undertaken on the chemical constituents of ethanol extract of aerial parts of Nyctanthes arbor-tristis Linn., and their determination of growth inhibitory activity against glioblastoma multiforme cell line (U87) and urease inhibitory activity. Six constituents were isolated including two new arbortristoside F tetraacetate (1) and arbortristoside G heptaacetate (2) and four known arborside A tetraacetate (3), arborside C pentaacetate (4), 6,7-di-O-acetyl-6β-hydroxyloganin hexaacetate (5) and nyctanthoside heptaacetate (6) iridoid glycoside acetates. Their structures were elucidated using spectroscopic methods, including 1D and 2D NMR and mass analyses. Compounds 3 and 6 showed significant growth inhibition of U87 cell line (76.41 and 87.62% inhibition) respectively while 2, 4 and 5 showed moderate inhibition. 3 and 6 showed notable urease inhibition (IC50 = 17.2 ± 0.4 and 17.2 ± 0.7 µM) respectively, and IC50 of 2, 4 and 5 were 23.8 - 56.3 µM. Compound 1 was inactive.PMID:38646805 | DOI:10.1080/14786419.2024.2340059

Source: Cell Research - April 22, 2024 Category: Cytology Authors: Talea Sana Sumbul Zehra Majid Khan Bina Shaheen Siddiqui Shabana Usman Simjee Sabira Begum Taibi B Hadda Source Type: research