Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics

In this study, we aimed to clarify the role of NRDC in vascular smooth muscle cell (VSMC) by generating VSMC-specific Nrdc knockout (VSMC-KO) mice. Our findings reveal that VSMC-KO mice also exhibit hypotension. Aortas isolated from VSMC-KO mice exhibited a weakened contractile response to phenylephrine, accompanied by reduced phosphorylation of myosin light chain 2 and decreased rhoA expression. VSMC isolated from VSMC-KO aortas showed a reduced increase in intracellular Ca2+ concentration induced by α-stimulants. These findings suggest that NRDC in VSMC regulates vascular contraction and blood pressure by modulating Ca2+ dynamics.PMID:38648679 | DOI:10.1016/j.bbrc.2024.149961

Source: Cell Research - April 22, 2024 Category: Cytology Authors: Mend Amar Batbaatar Takeshi Kinoshita Shinya Ikeda Kiyoto Nishi Hirotaka Iwasaki Narangerel Ganbaatar Mikiko Ohno Eiichiro Nishi Source Type: research