Viruses, Vol. 16, Pages 650: Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility

In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere (n = 150) and severe (n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19.

Source: Viruses - April 22, 2024 Category: Virology Authors: Kevin Matheus Lima de Sarges Fl ávia Póvoa da Costa Erika Ferreira dos Santos Marcos Henrique Damasceno Cantanhede Rosilene da Silva Adriana de Oliveira Lameira Ver íssimo Maria de Nazar é do Socorro de Almeida Viana Fab íola Brasil Barbosa Rodrigues Tags: Communication Source Type: research