Haemostatic gene variations in cervical cancer-associated venous thrombosis: considerations for clinical strategies

In this study, the predictive capability of haemostatic gene SNPs on CC-related VTE and their prognostic value regardless of VTE were explored. Six SNPs in haemostatic genes were evaluated. A total of 401 CC patients undergoing chemoradiotherapy were enrolled in a retrospective cohort study. The implications for the time to VTE occurrence and overall survival (OS) were assessed. CAT considerably impacted the CC patients ’ OS (log-rank test,P <  0.001).SERPINE1 rs2070682 (T  >  C) showed a significant association with the risk of CC-related VTE (CC/CT vs. TT, log-rank test,P = 0.002; C allele, Cox model, hazard ratio (HR) = 6.99 andP = 0.009), whileF2 rs1799963 (G  >  A) demonstrated an important prognostic value regardless of VTE (AA/AG vs. GG, log-rank test,P = 0.020; A allele, Cox model, HR = 2.76 andP = 0.026). For the remaining SNPs, no significant associations were detected. The polymorphismsSERPINE1 rs2070682 andF2 rs1799963 could be valuable tools in clinical decision-making, aiding in thromboprophylaxis and CC management, respectively.Visual Abstract
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research