Effects of hypertriglyceridemia with or without NEFA elevation on β-cell function and insulin clearance and sensitivity

CONCLUSION: In healthy non-obese subjects, mild acute hypertriglyceridemia directly reduces glucose tolerance, insulin sensitivity and clearance, and has selective and opposite effects on β-cell function that are neutralized by NEFAs. These findings provide new insight into plausible biological signals that generate and sustain insulin resistance and chronic hyperinsulinemia in the development of T2D.PMID:38635405 | DOI:10.1210/clinem/dgae276

Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Domenico Tric ò Eleni Rebelos Brenno Astiarraga Simona Baldi Tiziana Scozzaro Luca Sacchetta Martina Chiriac ò Andrea Mari Ele Ferrannini Elza Muscelli Andrea Natali Source Type: research