Deconstructing cancer with precision genome editing

Biochem Soc Trans. 2024 Apr 17:BST20230984. doi: 10.1042/BST20230984. Online ahead of print.ABSTRACTRecent advances in genome editing technologies are allowing investigators to engineer and study cancer-associated mutations in their endogenous genetic contexts with high precision and efficiency. Of these, base editing and prime editing are quickly becoming gold-standards in the field due to their versatility and scalability. Here, we review the merits and limitations of these precision genome editing technologies, their application to modern cancer research, and speculate how these could be integrated to address future directions in the field.PMID:38629716 | DOI:10.1042/BST20230984
Source: Biochemical Society Transactions - Category: Biochemistry Authors: Source Type: research