Unraveling the mechanisms of Sofosbuvir resistance in HCV NS3/4A protease: Structural and molecular simulation-based insights

In this study, the resistance mechanism of Sofosbuvir at the atomic level is proposed. The proposed drug-resistance mechanism will provide valuable guidance for the design of HCV drugs.PMID:38631585 | DOI:10.1016/j.ijbiomac.2024.131629
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research