Abnormal frequency of the memory B cell subsets and plasmablasts in patients with congenital severe hemophilia A: correlation with "Inhibitor" formation

CONCLUSION: This study is the first to demonstrate a dysregulated proportion of CD19+IgD+CD27+ non-class-switched memory B cells and CD19+CD27hiCD38hi plasmablasts in patients with severe HA. Therefore, strategies targeting memory B-cell/plasmablast differentiation may have promising outcomes in the management of inhibitor formation in patients with severe HA.PMID:38625415 | PMC:PMC11021380 | DOI:10.1007/s44313-024-00017-7

Source: Blood Research - April 16, 2024 Category: Hematology Authors: Omid Reza Zekavat Yasaman Movahednezhad Amin Shahsavani Sezaneh Haghpanah Negin Shokrgozar Hossein Golmoghaddam Mehdi Kalani Mohammad Reza Bordbar Nargess Arandi Source Type: research