Cancers, Vol. 16, Pages 1549: Prostate Tissue Microbiome in Patients with Prostate Cancer: A Systematic Review

Cancers, Vol. 16, Pages 1549: Prostate Tissue Microbiome in Patients with Prostate Cancer: A Systematic Review Cancers doi: 10.3390/cancers16081549 Authors: Daniela F. Ward Grados Onuralp Ergun Carly D. Miller Petr Gaburak Nana A. Frimpong Oluwatobi Shittu Christopher A. Warlick Some researchers have speculated that the prostatic microbiome is involved in the development of prostate cancer (PCa) but there is no consensus on certain microbiota in the prostatic tissue of PCa vs. healthy controls. This systematic review aims to investigate and compare the microbiome of PCa and healthy tissue to determine the microbial association with the pathogenesis of PCa. We searched MEDLINE, Embase, and Scopus databases. Articles were screened by two independent and blinded reviewers. Literature that compared the prostatic tissue microbiome of patients with PCa with benign controls was included. We found that PCa may be associated with increased Propionibacterium acnes, the herpesviridae and papillomaviridae families, and Mycoplasma genitalium, but definitive conclusions cannot be drawn from the existing data. Challenges include the difficulty of obtaining uncontaminated tissue samples and securing tissue from healthy controls. As a result, methods are varied with many studies using cancerous and “healthy” tissue from the same prostate. The organisms chosen for each study were also highly variable, making it difficult to compare studies. These...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Systematic Review Source Type: research