Neutrophil antigen antibodies affect engraftment and secondary graft failure in hematopoietic progenitor cell transplantation

DISCUSSION: The study reveals a potential link between anti-HNA and HPC transplantation outcomes not previously reported. Patients with anti-HNA had a lower proportion and cumulative incidence of achieving donor chimerism. Additionally, anti-HNA status affected the time for neutrophil engraftment, with a slower rate of neutrophil engraftment and increased risk of secondary failure in patients with anti-HNA.PMID:38634344 | DOI:10.1111/trf.17830
Source: Transfusion - Category: Hematology Authors: Source Type: research