Distinct ER and PR expression patterns significantly affect the clinical outcomes of early HER2-positive breast cancer: A real-world analysis of 871 patients treated with neoadjuvant therapy

CONCLUSIONS: HER2-positive breast cancer exhibited three distinct HR-specific subtypes with varying clinical manifestations and treatment responses. These findings suggest personalized treatment strategies considering ER and PR expression patterns, emphasizing the need for further investigations to unravel molecular traits underlying HER2-positive breast cancer with distinct HR expression patterns.PMID:38615482 | DOI:10.1016/j.breast.2024.103733

Source: Breast - April 14, 2024 Category: Cancer & Oncology Authors: Haizhu Chen Xiujuan Gui Ziwei Zhou Fengxi Su Chang Gong Shunrong Li Wei Wu Nanyan Rao Qiang Liu Herui Yao Source Type: research