A Perspective on the Exogenous Redox Regulation of Transfused RBCs Subject to the Storage Lesion

Granted with a potent ability to interact with and tolerate oxidative stressors, RBCs scavenge most reactive oxygen and nitrogen species (RONS) generated in circulation. This essential non-canonical function, however, renders RBCs susceptible to damage when vascular RONS are generated in excess, making vascular redox imbalance a common etiology of anemia, and thus a common indication for transfusion. This accentuates the relevance of impairments in redox metabolism during hypothermic storage, as the exposure to chronic oxidative stressors upon transfusion could be exceedingly deleterious to stored RBCs.

Source: Transfusion and Apheresis Science - April 17, 2024 Category: Hematology Authors: Nishaka William, Jason P. Acker Source Type: research