Viperin inhibits interferon- γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling

ConclusionsThis study highlights the involvement of TBK1-IKK ε-IRF3 axis and JAK-STAT signaling pathways in Viperin-suppressed IFN-γ production in Mtb infected macrophages, and identifies a novel mechanism of Viperin on negatively regulating host immune response to Mtb infection.

Source: Inflammation Research - April 16, 2024 Category: Research Source Type: research