Dissecting the effect of ALS mutation S375G on the conformational properties and aggregation dynamics of TDP-43 < sub > 370-375 < /sub > fragment

This study offers for the first time of molecular insights into the S375G mutation affecting the aggregation of TDP-43370-375 at the atomic level, and may open new avenues in the development of future site-specific mutation therapeutics.PMID:38615537 | DOI:10.1016/j.bpc.2024.107230

Source: Biophysical Chemistry - April 14, 2024 Category: Chemistry Authors: Zhengdong Xu Jianxin Zhang Jiaxing Tang Yehong Gong Yu Zou Qingwen Zhang Source Type: research