The procoagulant signature of cancer cells drives fibrin network formation in tumor microenvironment and impacts its quality. Implications in cancer cell migration and the resistance to anticancer agents
Cancer cells induce hypercoagulability in the tumoral microenvironment by expressing Tissue Factor (TF). We aimed to study the impact of the procoagulant signature of cancer cells on the quality and structure of fibrin network. We also studied the impact of fibrin clot shield (FCS) on the efficiency of anticancer agents and the migration of cancer cells.
Source: Thrombosis Research - Category: Hematology Authors: Huong Chi Mai Tran, Elisabeth Mbemba, No émie Mourot, Beshoy Faltas, Aurélie Rousseau, Elmina Lefkou, Michèle Sabbah, Patrick Van Dreden, Grigoris Gerotziafas Tags: Full Length Article Source Type: research