Essential role of CD38 in platelet aggregation through the PKC-mediated internalization and activation

CONCLUSION: PKC is involved in many signaling pathways. Specifically, PKC is involved in the internalization of CD38 via MHCIIA in CD38+/+ wild-type (WT) and CD38-/- knockout mice (KO). CD38 generates calcium-mobilizing agents that act on specific receptors of the calcium stores. Calcium triggered platelet aggregation while serving as a secondary messenger.PMID:38505670 | PMC:PMC10945299 | DOI:10.34172/bi.2023.27780

Source: BioImpacts - March 20, 2024 Category: Research Authors: Mazhar Mushtaq Maira Mahmood Uzma Jabbar Uh-Hyun Kim Source Type: research